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Перекрестная аллергия Оглавление Информация в статье не заменяет консультацию врача.
Что такое перекрестная пищевая аллергия? Перекрёстная пищевая аллергия (оральный аллергический синдром, синдром «пыльца-продукт») – разновидность пищевой аллергической реакции, которая преимущественно возникает у людей с аллергией на пыльцу растений1 .
Чаще всего оральный аллергический синдром возникает в результате перекрёстной аллергии между белками, содержащимися в пыльце растений, латексе и некоторых продуктах1 . Как ни странно, но в пыльце растений и в некоторых фруктах, овощах, орехах содержатся одинаковые белки, и при попадании в организм иммунная система ошибочно принимает их за пыльцу и запускает каскад аллергического воспаления.
Появляется перекрёстная аллергия после употребления некоторых сырых (температурно-необработанных) фруктов, овощей, специй, орехов. Также описана перекрестная аллергия, связанная со спорами плесневых грибов, латексом, клещами домашней пыли1 .
В основном симптомы затрагивают губы, рот, язык, горло и проявляются в виде отёчности, зуда и покраснения.
Симптомы перекрёстной аллергии Особенности перекрестной аллергии Перекрёстная пищевая аллергия чаще всего вызывается приемом в пищу сырых овощей и фруктов. Реакция на те же продукты после приготовления с использованием высоких температур чаще всего либо не происходит вовсе, либо протекает с минимальными клиническими проявлениями. В некоторых случаях реакцию вызывает только кожура фруктов и овощей. После её удаления продукт может спокойно употребляться в пищу. Сырые овощи Термическая обработка Удаление кожуры Перекрёстная аллергия обычно поражает людей с пыльцевой аллергией. Особенно с аллергией на берёзу, злаковые травы, полынь, амброзию. 75% процентов пациентов с аллергией на пыльцу берёзы имеют симптомы перекрестной аллергии3 . Чаще всего перекрёстная аллергия появляется после дебюта сезонной. Иногда спустя много лет. У ряда людей симптомы проявляются только в период цветения «виновных» аллергенов. Чем выше концентрация пыльцы в воздухе, тем сильнее проявляется реакция. Симптомам пищевой аллергии подвержены люди с аллергией на латекс. Примеры перекрестной аллергии Распространённые перекрёстные аллергические реакции Симптомы аллергии Перекрестная пищевая аллергия может стать причиной появления таких симптомов, как:
аллергический ринит (зуд в носу, насморк, чихание)аллергический конъюнктивит (зуд глаз, слезотечение)крапивница, аллергический дерматит (зуд кожи, особенно вокруг рта, появление волдырей) Ринит Конъюнктивит Крапивница Первая помощь при данных проявлениях: приём антигистаминного препарата (например, Супрастинекс® в возрастной дозировке) и контроль за состоянием. При ухудшении – вызов скорой медицинской помощи3 .
Супрастинекс® в виде капель разрешён к применению с возраста 2 лет по 5 капель на 1 приём 2 раза в сутки (вплоть до 6 летнего возраста), а от 6 лет и старше – 20 капель 1 раз в сутки5 .
Также с возраста 6 лет уже возможен приём препарата в таблетках – 5 мг, 1 таблетка 1 раз в сутки5 .
Про эффективность
1 таблетка помогает защищать организм от действия аллергенов на 24 часа5
Про безопасность
Высокий профиль безопасности, подходит для детей с 2х лет5
Низкая вероятность сонливости
Позволяет сохранить концентрацию в течение дня*
Про длительный прием
Подходит для длительного применения у детей и взрослых без эффекта привыкания*
Если симптомы аллергии не проходят или даже нарастают, необходимо вызвать скорую медицинскую помощь.
Симптомы перекрестной аллергии обычно относятся к немедленным и возникают через 1–5 минут после попадания аллергена в организм. Лёгкие и среднетяжелые реакции также быстро и стихают, достаточно просто прекратить контакт с аллергеном и принять антигистаминный препарат2 .
Прочие симптомы перекрестной аллергии Симптомы перекрёстной аллергии у каждого человека могут проявляться по-разному. Одним из частых симптомов также может являться оральный аллергический синдром, характеризующийся покалыванием и зудом во рту, в области губ, языка.
Прочие симптомы перекрёстной аллергии Редкие (жизнеугрожающие) симптомы перекрестной аллергии 2
выраженное затруднение дыхания, свистящее дыхание, хрипы в груди снижение уровня сознания, бледность, холодный пот полная потеря сознания Лечение во всех таких ситуациях подразумевает немедленный вызов бригады скорой медицинской помощи и экстренную госпитализацию в стационар3 .
О перекрестной аллергии смотрите в коротком видео:
В видео рассказывается, что такое перекрестная аллергия, как может проявляться заболевание и как можно предотвратить нежелательные реакции.
Главные перекрестные аллергены Наиболее частые перекрёстно-реагирующие продукты представлены ниже. Но это не значит, что если имеется установленная аллергия на пыльцу, то необходимо строго исключать все продукты из списка. Решение о назначении диеты принимается врачом-аллергологом после тщательного опроса и обследования.
Аллергены и перекрестно-реагирующие продукты 1. Пыльца березы (ольхи, лещины) – симптомы поллиноза чаще всего возникают с апреля по май
Перекрестные аллергены:
миндаль яблоко абрикос бразильский орех морковь кешью сельдерей вишня фундук киви манго персик и нектарин лук апельсин петрушка груша картофель (кожура сырого – симптомы при чистке) помидор грецкий орех 1,3 Перекрестные аллергены березы Перекрёстная аллергия на берёзу 2. Луговые/злаковые травы – симптомы поллиноза возникают с середины июня по конец июля Перекрестные аллергены:
бобы киви чечевица дыня горох арахис картофель томат соя арбуз пшеница 1,3 Перекрестные аллергены луговых/злаковых трав Перекрёстная аллергия на луговые травы 3. Пыльца полыни – симптомы поллиноза возникают в августе – сентябре
Перекрестные аллергены:
банан морковь сельдерей зеленый лук кориандр фенхель дыня петрушка пастернак арахис подсолнечник (семечки, масло)1,3 Перекрестные аллергены пыльцы полыни Перекрёстная аллергия на полынь 4. Пыльца амброзии
Перекрестные аллергены:
банан дыня арбуз цукини огурец 1,3 Перекрестные аллергены пыльцы амброзии Перекрёстная аллергия на амброзию 5. Латекс Перекрестные аллергены:
авокадо банан каштан цитрусовые киви виноград манго дыня папайя маракуйя персик арахис перец ананас слива томат 1,3 Перекрестные аллергены латекса Перекрёстная аллергия на латекс 6. Споры плесневых грибов Перекрестные аллергены:
некоторые съедобные грибы микопротеин (альтернативный источник протеина, растительная замена мясу). сыры с плесенью сметана кисломолочные продукты (кефир, простокваша) дрожжи вино пиво сидр различные соусы (кетчуп, майонез, Вустерский соус, соевый соус) сухофрукты перезрелые фрукты, особенно арбузы, дыни шпинат4 Перекрестные аллергены спор плесневых грибов Перекрёстная аллергия на споры грибов 7. Клещи домашней пыли
Перекрестные аллергены: морепродукты (ракообразные, моллюски)3
8. Кошачья перхоть, шерсть, слюна
Перекрестные аллергены: свинина3
9. Перья птиц, экскременты
Перекрестные аллергены:
яйцо мясо птицы (курица в первую очередь)3 Перекрёстная аллергия на моллюсков и ракообразных встречается нечасто, но при этом всегда надо иметь в виду, что этот вид пищевой аллергии сопряжен с высоким риском тяжёлых реакций!
Жизнь с перекрестной пищевой аллергией 1. Избегать продуктов, провоцирующих аллергическую реакцию Очень важно избегать употребления фруктов и овощей, которые провоцируют развитие симптомов аллергии, особенно в сыром, термически необработанном виде. Однако всё это очень индивидуально.
Например, некоторые люди совсем не реагируют на очищенные фрукты, другие могут спокойно есть совсем неспелые или немного недозрелые фрукты, а также фрукты, только что сорванные с дерева. Третьи замечают, что один сорт яблок вызывает выраженные реакции, тогда как другой сорт не вызывает никакой реакции вообще. В основном большинство реагирующих на сырые фрукты людей вполне спокойно могут переносить их же после температурной обработки: в виде компотов, варенья.
Орехи и сельдерей необходимо избегать даже после их температурной обработки, так как именно эти продукты ассоциируются с высоким риском тяжелых аллергических реакций.
Далеко не все продукты из списка потенциально опасных могут вызывать реакцию. Иногда это 1 -2 продукта, при этом с годами список может расширяться. Нужно фиксировать те продукты, которые уже вызвали реакцию, чтобы избегать их в будущем. Остальные же продукты из списка можно употреблять в пищу.
2. Всегда иметь при себе антигистаминный препарат У большинства людей с перекрёстной пищевой аллергией симптомы носят лёгкий, хорошо поддающийся лечению характер. Целесообразно всегда иметь антигистаминный препарат в быстродействующей форме, например капли Супрастинекс® , чтобы при первых кожных симптомах аллергической реакции (крапивница, зуд кожи) была возможность принять лекарство.
Если же уже были зафиксированы ситуации тяжёлых реакций, вызванных пищевой перекрёстной аллергией, то необходимо непременно обратиться к аллергологу, чтобы получить рекомендации по экстренным действиям2 .
Диагностика перекрёстной аллергии Диагностика перекрёстной пищевой аллергии в большинстве случаев не представляет никакой сложности и основывается в первую очередь на тщательном опросе врача. После него, как правило, диагноз уже не вызывает сомнений. Однако, если сомнения всё ещё остаются, то возможно проведение исследования специфических иммуноглобулинов (Ig E) как к цельному продукту, так и к белкам, объединяющим ингаляционный и пищевой аллерген2 .
Лечение перекрёстной аллергии Каких-то особых подходов к лечению данного вида аллергии нет. Для лечения таких проявлений перекрестной аллергии, как аллергический ринит, аллергический конъюнктивит или аллергодерматозы в основном используются антигистаминные препараты, как первого поколения, так и второго, например препарат Супрастинекс® (левоцетиризин) в виде капель, который можно применять уже с двухлетнего возраста. Эффект после приёма препарата сохраняется на протяжении 24 часов5 .
Аллергенспецифическая иммунотерапия и перекрёстная аллергия Аллергенспецифическая иммунотерапия («вакцинация» от аллергии) проводится на большинство выдыхаемых аллергенов (пыль, пыльца), но не проводится на пищевые продукты. Эффективность этой методики в отношении перекрёстных реакций не так уж высока в сравнении с эффективностью в отношении дыхательных симптомов2 .
Автор статьи
Борисова Татьяна Вадимовна
ИМЕЮТСЯ ПРОТИВОПОКАЗАНИЯ. НЕОБХОДИМО ПРОКОНСУЛЬТИРОВАТЬСЯ СО СПЕЦИАЛИСТОМ Источники: Popescu FD. Cross-reactivity between aeroallergens and food allergens. World J Methodol. 2015 Jun 26;5(2):31-50. doi: 10.5662/wjm.v5.i2.31. PMID: 26140270; PMCID: PMC4482820. Баранов АА, Намазова-Баранова ЛС, Хаитов РМ, Ильина НИ, Курбачева ОМ, Новик ГА и соавт. Федеральные клинические рекомендации по оказанию медицинской помощи детям с пищевой аллергией. М.: Союз педиатров России. 2018 Price A., Ramachandran S., Smith G.P. et al. Oral allergy syndrome (Pollen-food allergy syndrome). Int J Dermatitis. 2015;26:78–88. Haiyan Xing, Jianyong Wang, Yuemei Sun, Hongtian Wang, "Recent Advances in the Allergic Cross-Reactivity between Fungi and Foods", Journal of Immunology Research , vol. 2022, Article ID 7583400, 10 pages, 2022. На основании инструкции по медицинскому применению препарата Супрастинекс® (рег. №: ЛСР-008568/10, ЛП-000225).* при применении в терапевтических дозах. На основании инструкции по медицинскому применению препарата Супрастинекс® (рег. №: ЛСР-008568/10, ЛП-000225)